The American Dental Association (ADA) estimates that 100 million mercury dental fillings are placed within the mouths of people in the USA every year. Others have estimated that 180 million people in the USA bear mercury dental fillings. Mercury is an important toxin source to consider in health conditions with "no known cause, and no known cure".

Mercury exposure stresses the immune system of every person who has them. Both a properly functioning immune system and the body's method for excreting mercury consume the antioxidant enzyme Glutathione. When mercury depletes the body of Glutathione, it has a direct negative effect on the immune system's ability to respond properly to infections and cancer.